This article explores how challenges such as sequence optimization, immune activation and off-target effects are being ...

RNA plays a vital role in how our genes are expressed and how diseases develop. Yet, because RNA molecules constantly change shape, understanding how they work has long been a major scientific ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 4 (January 25, 2022), pp. 1-11 (11 pages) RNA is a ubiquitous biomolecule that can serve as both catalyst ...

Researchers have used cryo-EM and computational tools to visualize ribozyme assembly, shedding light on life's most versatile ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure. A recent study ...

In 2020, Juan Alfonzo, a professor of molecular biology, cell biology and biochemistry, began a project out of “pure COVID boredom.” Now, that project may become the largest scientific undertaking ...

The original version of this story appeared in Quanta Magazine. For a molecule of RNA, the world is a dangerous place. Unlike DNA, which can persist for millions of years in its remarkably stable, ...

Researchers have sequenced the oldest RNA ever recovered, taken from a woolly mammoth frozen for nearly 40,000 years. The RNA reveals which genes were active in its tissues, offering a rare glimpse ...