This article explores how challenges such as sequence optimization, immune activation and off-target effects are being ...

Researchers from Stockholm University have—for the first time ever—managed to successfully isolate and sequence RNA molecules from Ice Age woolly mammoths. These RNA sequences are the oldest ever ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 4 (January 25, 2022), pp. 1-11 (11 pages) RNA is a ubiquitous biomolecule that can serve as both catalyst ...

Researchers have used cryo-EM and computational tools to visualize ribozyme assembly, shedding light on life's most versatile ...

UC Vice President for Research Patrick Limbach is a key figure in the National Academies’ massive undertaking to sequence RNA in the next 15 years. A chemist who leads the University of Cincinnati’s ...

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure. A recent study ...

In 2020, Juan Alfonzo, a professor of molecular biology, cell biology and biochemistry, began a project out of “pure COVID boredom.” Now, that project may become the largest scientific undertaking ...

The original version of this story appeared in Quanta Magazine. For a molecule of RNA, the world is a dangerous place. Unlike DNA, which can persist for millions of years in its remarkably stable, ...

Researchers have sequenced the oldest RNA ever recovered, taken from a woolly mammoth frozen for nearly 40,000 years. The RNA reveals which genes were active in its tissues, offering a rare glimpse ...