Phase I and Pharmacologic Study of Oral ZD9331, A Novel Nonpolyglutamated Thymidylate Synthase Inhibitor, in Adult Patients With Solid Tumors ABSTRACT: Aberrant gene expression is critical for tumor ...

Most pharmaceuticals sold today have their origin in a biochemistry laboratory. Drug discovery has traditionally started with a biochemical pathway implicated in a pathophysiological process. An ...

The human genome project was undertaken to determine the human DNA sequence and analyze variation among individuals. To make use of this information, tools were developed that could collect and ...

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand ...

An international research team led by the University of Vienna has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

Processes Involved in Using DNA Microarray Instrumentation in Protein Microarray Workflow Protein microarrays offer the ability to measure protein expression and antibody binding in a high-throughput ...

For most researchers DNA microarrays are synonymous with high-throughput gene expression analysis. But they also are invaluable genotyping tools. Now that the International HapMap Project (see article ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...