Researchers identified mechanisms that limit CD4+ Th1 cell differentiation during chronic viral infection. They discovered an intermediate precursor subset and showed that PD-1/PD-L1 signaling and the ...

There is a high unmet need for accessible, affordable, and high-quality fertility care, as approximately 1 in 6 people are affected by infertility worldwide. While meiotic failure is a major cause of ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

A comprehensive map of aberrant hematopoiesis in people with acute myeloid leukemia defines specific cell states and potential therapeutic targets. The team used their reference map for normal ...

A multi-institutional study led by researchers at UNC Lineberger Comprehensive Cancer Center, the Salk Institute for Biological Studies, and UC San Diego has uncovered new genetic rules that determine ...

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer ...

Two of them were responsible for overexpression in the cellular differentiation process, while one was responsible for inhibition. The finding could be used to study and potentially reverse the spread ...

Cells operate on rules not vibes, including when on the precipice of persisting or perishing. Yet, with prior research ...

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer. The sugar glucose, which ...